![]() The proposed method has numerous advantages including procedure simplicity, short reaction times, low cost, good to excellent yields, reusability of the catalyst and mild and environmentally benign conditions. The stability of the recycled catalyst was investigated. The catalyst was recovered and reused for five cycles without a considerable decrease in catalytic activity. The conditions for optimal reaction yield and time were: amount of catalyst = 0.34 mmol, temperature = 60☌ and molar ratio of amine to alcohol = 1.2. The optimization of the reaction conditions was investigated using the response surface method, and involving the Box–Behnken design matrix. Various secondary amines were synthesized from primary amines and alcohols in good to excellent yields, with water as the only by-product. The supported ferric perchlorate (Fe(ClO 4) 3/SiO 2) revealed high efficiency and selectivity for N-alkylation of aromatic amines with alcohols to provide alkylated amines. The catalyst was characterized using various techniques. Fe(ClO 4) 3 was prepared from mixing iron(III) hydroxide and perchloric acid and adsorbed on silica gel. Anilines have shown that the products of these one-electron reactions are deri- vatives. An efficient method for the N-alkylation of poorly nucleophilic amines using ferric perchlorate immobilized on SiO 2 as a catalyst is described. Solutions of perchloric acid to the corresponding derivatives of 4.
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